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Epub 2015 Sep 28.Adv Drug Deliv Rev. In theory, these cells — known as induced pluripotent stem cells (iPSCs) — are suitable for various purposes, including disease modelling, autologous cell therapy… doi: 10.7717/peerj.4370. Besides these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells, these cells hold an immense potential for cell-based therapies, and for the discovery of new or personalized pharmacological treatments for many disorders. 2011 Apr 30;63(4-5):324-30. doi: 10.1016/j.addr.2011.01.013. Yamanaka and Thomson, respectively, who pioneered and generated stem cells from human skin through ectopic expression of four genes (Oct3/4, Sox2, c-Myc, and Klf4, or Oct3/4, Sox2, Nanog, and Lin28). Brain Res. 2011 Apr 30;63(4-5):324-30. doi: 10.1016/j.addr.2011.01.013. eCollection 2020 Mar 24. We introduce the potential held by iPSC for research and development of novel health-related applications. Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging. Clipboard, Search History, and several other advanced features are temporarily unavailable. Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging. In addition, iPSC can be generated from somatic cells harvested from normal individuals or patients, and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible before. Induced pluripotent stem cells, a giant leap for mankind therapeutic applications. Free PMC article Induced pluripotent cells were first described in 2006 by Japanese physician and researcher Shinya Yamanaka and colleagues. A major advantage of human iPSC, compared to the pluripotent embryonic stem cells, is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human blastocysts. eCollection 2020 Mar 24. doi: 10.3791/4003.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 May 1;1638(Pt A):30-41. doi: 10.1016/j.brainres.2015.09.023. 2012 Nov 29;(69):e4003. Induced pluripotent stem cells, a giant leap for mankind therapeutic applications. 2014 Aug;22(4):883-8. doi: 10.7534/j.issn.1009-2137.2014.04.001.PeerJ. eCollection 2018.Assoun EN, Meyer AN, Jiang MY, Baird SM, Haas M, Donoghue DJ.Oncotarget. Unable to load your collection due to an error This site needs JavaScript to work properly. Free PMC article Induced pluripotent stem cells (iPS cells) differ from embryonic stem cells (ES cells), which form the inner cell mass of an embryo but also are pluripotent, eventually giving rise to all the cell types that make up the body. Epub 2015 Sep 28.Adv Drug Deliv Rev. Induced pluripotent stem cells, a giant leap for mankind therapeutic applications. Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer biology and aging. This approach may be used to determine the adequate treatment plan to specific patients and to limit side effects or non-responsiveness experienced by conventional clinical approaches supported by medical history and examinations, and test results to implement the treatment based on generic clinical approaches; B: iPSC-derived from patients may also be corrected for genetic defects and consequently used to treat the patients in cell-based or regenerative therapies (orange panel); C: iPSC may be used to derive immune cells to eliminate cancer cells, or to be inactivated and injected to vaccinate people against cancer cells; D: iPSC used to study developmental processes, model diseases and test drugs to assess toxicity in specific cell types (yellow panel); E: iPSC originated from non-diseased individuals are being characterized and preserved in Biobanks worldwide for allogenic cell-based therapies in HLA matched patients (green panel). We introduce the potential held by iPSC for research and development of novel health-related applications. 2018 May 11;6:e4370. Besides these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells, these cells hold an immense potential for cell-based therapies, and for the discovery of new or personalized pharmacological treatments for many disorders. Baishideng Publishing Group Inc. Induced pluripotent stem cells (iPS cells) were first generated by two research teams led by Drs.
A major advantage of human iPSC, compared to the pluripotent embryonic stem cells, is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of … Applications of human induced pluripotent stem cells. Free PMC article Finally, we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells. iPSC: Induced pluripotent stem cells.
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